Motif ID: TFAP2{A,C}.p2

Z-value: 0.784


Transcription factors associated with TFAP2{A,C}.p2:

Gene SymbolEntrez IDGene Name
TFAP2A 7020 transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TFAP2C 7022 transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
TFAP2Achr6_-_10412606,
chr6_-_10415438
0.714.9e-02Click!
TFAP2Cchr20_+_552043070.294.9e-01Click!


Activity profile for motif TFAP2{A,C}.p2.

activity profile for motif TFAP2{A,C}.p2


Sorted Z-values histogram for motif TFAP2{A,C}.p2

Sorted Z-values for motif TFAP2{A,C}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TFAP2{A,C}.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chrX_+_152953751 0.834 NM_001142805
NM_005629
SLC6A8

solute carrier family 6 (neurotransmitter transporter, creatine), member 8

chr7_-_44365019 0.807 NM_001220
NM_172078
NM_172079
NM_172080
NM_172081
NM_172082
NM_172083
NM_172084
CAMK2B







calcium/calmodulin-dependent protein kinase II beta







chr16_+_22825806 0.770 NM_006043
HS3ST2
heparan sulfate (glucosamine) 3-O-sulfotransferase 2
chr16_+_68679198 0.767 CDH3
cadherin 3, type 1, P-cadherin (placental)
chr22_+_45098091 0.666 NM_181334
PRR5-ARHGAP8
PRR5
PRR5-ARHGAP8 readthrough
proline rich 5 (renal)
chr2_+_18059923 0.611 NM_002252
KCNS3
potassium voltage-gated channel, delayed-rectifier, subfamily S, member 3
chr16_+_68679229 0.588 CDH3
cadherin 3, type 1, P-cadherin (placental)
chr9_-_140196702 0.504 NM_001004354
NRARP
NOTCH-regulated ankyrin repeat protein
chr8_+_86376130 0.504 NM_000067
CA2
carbonic anhydrase II
chr8_+_61591358 0.487 CHD7
chromodomain helicase DNA binding protein 7
chr8_+_104512975 0.485 NM_001100117
RIMS2
regulating synaptic membrane exocytosis 2
chr6_-_4079390 0.476 NM_173563
C6orf146
chromosome 6 open reading frame 146
chr17_+_9548853 0.461 NM_153210
USP43
ubiquitin specific peptidase 43
chr18_-_74207145 0.445 NM_014643
ZNF516
zinc finger protein 516
chr18_+_33877630 0.441 NM_025135
FHOD3
formin homology 2 domain containing 3
chr1_+_233463513 0.428 NM_032435
KIAA1804
mixed lineage kinase 4
chr2_+_85360373 0.427 NM_031283
TCF7L1
transcription factor 7-like 1 (T-cell specific, HMG-box)
chr8_-_127570710 0.403 NM_174911
FAM84B
family with sequence similarity 84, member B
chr22_+_45098046 0.400 NM_181333
PRR5
proline rich 5 (renal)
chr22_+_40390935 0.395 NM_138435
FAM83F
family with sequence similarity 83, member F

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 102 entries
enrichment   p-value GO term description
1.41 3.46e-04 GO:0032446 protein modification by small protein conjugation
1.41 4.74e-02 GO:0016569 covalent chromatin modification
1.38 5.91e-03 GO:0016567 protein ubiquitination
1.35 2.35e-03 GO:0070647 protein modification by small protein conjugation or removal
1.34 3.29e-03 GO:0071495 cellular response to endogenous stimulus
1.33 2.14e-03 GO:0016568 chromatin modification
1.33 1.90e-02 GO:0032870 cellular response to hormone stimulus
1.31 2.96e-05 GO:0000278 mitotic cell cycle
1.31 1.83e-04 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
1.29 4.81e-06 GO:0006468 protein phosphorylation
1.29 2.58e-05 GO:0010558 negative regulation of macromolecule biosynthetic process
1.28 1.81e-04 GO:2000113 negative regulation of cellular macromolecule biosynthetic process
1.27 5.41e-05 GO:0009890 negative regulation of biosynthetic process
1.27 1.40e-04 GO:0031327 negative regulation of cellular biosynthetic process
1.27 3.78e-04 GO:0007167 enzyme linked receptor protein signaling pathway
1.26 2.92e-15 GO:0006464 protein modification process
1.26 6.35e-04 GO:0009719 response to endogenous stimulus
1.26 2.80e-03 GO:0009725 response to hormone stimulus
1.26 2.80e-03 GO:0045934 negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.26 7.78e-03 GO:0016071 mRNA metabolic process

Gene overrepresentation in compartment category:

Showing 1 to 20 of 33 entries
enrichment   p-value GO term description
1.65 1.41e-02 GO:0030426 growth cone
1.64 1.52e-02 GO:0030427 site of polarized growth
1.43 2.34e-03 GO:0030424 axon
1.36 3.40e-03 GO:0005635 nuclear envelope
1.27 2.89e-02 GO:0048471 perinuclear region of cytoplasm
1.26 1.67e-02 GO:0043005 neuron projection
1.22 1.19e-03 GO:0044451 nucleoplasm part
1.21 7.57e-13 GO:0044428 nuclear part
1.21 4.37e-07 GO:0005654 nucleoplasm
1.20 4.76e-09 GO:0031981 nuclear lumen
1.20 9.13e-03 GO:0031967 organelle envelope
1.20 1.45e-02 GO:0031975 envelope
1.19 9.29e-10 GO:0005829 cytosol
1.18 4.37e-03 GO:0005794 Golgi apparatus
1.17 2.21e-08 GO:0031974 membrane-enclosed lumen
1.17 4.78e-08 GO:0070013 intracellular organelle lumen
1.16 5.21e-08 GO:0043233 organelle lumen
1.15 3.77e-22 GO:0005634 nucleus
1.15 3.04e-04 GO:0012505 endomembrane system
1.13 4.24e-18 GO:0044444 cytoplasmic part

Gene overrepresentation in function category:

Showing 1 to 20 of 30 entries
enrichment   p-value GO term description
1.39 3.82e-04 GO:0016881 acid-amino acid ligase activity
1.38 1.81e-07 GO:0004674 protein serine/threonine kinase activity
1.37 3.69e-04 GO:0016879 ligase activity, forming carbon-nitrogen bonds
1.37 5.20e-03 GO:0019787 small conjugating protein ligase activity
1.36 1.57e-02 GO:0004842 ubiquitin-protein ligase activity
1.32 8.71e-09 GO:0016773 phosphotransferase activity, alcohol group as acceptor
1.32 1.28e-02 GO:0008134 transcription factor binding
1.31 1.48e-06 GO:0004672 protein kinase activity
1.29 3.63e-08 GO:0016301 kinase activity
1.29 8.98e-04 GO:0019904 protein domain specific binding
1.29 4.10e-02 GO:0016563 transcription activator activity
1.27 2.12e-06 GO:0019899 enzyme binding
1.25 2.04e-06 GO:0016772 transferase activity, transferring phosphorus-containing groups
1.22 1.42e-03 GO:0042802 identical protein binding
1.21 1.29e-02 GO:0046983 protein dimerization activity
1.20 5.06e-03 GO:0003723 RNA binding
1.18 2.30e-03 GO:0030528 transcription regulator activity
1.17 7.38e-45 GO:0005515 protein binding
1.16 5.44e-08 GO:0000166 nucleotide binding
1.16 1.97e-04 GO:0030554 adenyl nucleotide binding